<h4>Background and objectives</h4>Pathogenic variants in the <i>SCN2A</i> gene, encoding the α-subunit type 2 of the voltage-gated sodium channel Na<sub>V</sub>1.2, cause a phenotypic spectrum including 4 major disorders as benign familial infantile seizures, developmental and epileptic encephalopathy, intellectual disability, and autism. The gene discussed is SCN2A; the disease is autism.