DISC1 (Disrupted-In-Schizophrenia 1) was uniquely upregulated across TSA-treated neurons, AD-associated neuronal subpopulations, and protective microglial subtypes.<h4>Discussion</h4>DISC1 represents a convergent therapeutic target for AD, mediating TSA's neuroprotective effects through pathways regulating GSK3β, mitochondrial transport, and synaptic plasticity, providing a mechanistic framework for developing AD therapeutics. The gene discussed is GSK3B; the disease is Alzheimer disease.