BCL2L1 and rheumatoid arthritis: The mQTL signals based on summary-data-based MR analysis show that the genetically regulated methylation variations at the cg12873919 (odds ratio [OR] = 0.91, 95% CI [0.84-0.99]) and cg13989999 (OR = 0.90, 95% CI [0.82-1.00]) sites of the BCL2L1 gene are negatively associated with RA risk and may mediate disease risk by upregulating gene expression (OR = 0.82, 95% CI [0.76-0.88] and OR = 0.78, 95% CI [0.71-0.87]).