Applying the JAK2V617F myeloproliferative neoplasms (MPNs) oncogene-driver model, in which HIF-1α is stabilised in normoxia (20% O<sub>2</sub>), we sought to determine whether the modality of HIF-1 activation directs its function. The gene discussed is HIF1A; the disease is myeloproliferative neoplasm.