CLDN6 and ovarian cancer: Our study provides insights into the biology and plasticity of CLDN6-positive cells in EOC heterogeneity and highlights the clinical significance of CLDN6-targeting therapies for ovarian cancer treatment.<h4>Significance</h4>CLDN6-positive ovarian cancer cells exhibit remarkable plasticity influenced by microenvironmental factors and chemotherapy, providing critical insights for understanding the biology of ovarian cancer progression and optimizing CLDN6-targeting therapy.