Furthermore, Western blot results indicated elevated phosphorylated AKT levels in BPH cells with IL1RA knockdown, and phosphorylated AKT and GSK-3[Formula: see text] levels were reduced in C4-2B and LNCap cells that overexpressed IL1RA.<h4>Conclusion</h4>This study revealed that IL1RA low expression is associated with PCa progression. The gene discussed is AKT1; the disease is posterior cortical atrophy.