Current research hotspots primarily focus on the regulatory effects of MD on blood glucose homeostasis, insulin sensitivity, lipid metabolism, and blood pressure in MetS patients, as well as the mechanisms by which bioactive components (e.g., polyphenols, unsaturated fatty acids, and vitamins) promote metabolic health through anti-inflammatory, antioxidant, and insulin-sensitizing pathways. The gene discussed is INS; the disease is metabolic syndrome.