The performance of the model was evaluated using receiver operating characteristic curves, calibration curves, and cross-validation.<h4>Results</h4>Plasma GFAP and NFL levels showed a significant gradient change: APS group (GFAP: 89.9 pg./mL; NFL: 77.3 pg./mL) > PD group (GFAP: 47.1 pg./mL; NFL: 50.0 pg./mL) > HC group (GFAP: 22.1 pg./mL; NFL: 37.5 pg./mL; <i>p</i> < 0.05). The gene discussed is GFAP; the disease is Parkinson disease.