<h4>Objective</h4>This study evaluates genotype-phenotype correlations in <i>CRB1</i>-retinopathies using standardized phenotypic classification and comprehensive analysis of Crumbs homolog 1 (CRB1)-A and CRB1-B involvement alongside in silico protein modeling analysis.<h4>Design</h4>Retrospective multicenter cohort study.<h4>Subjects</h4>A total of 389 patients with biallelic disease-causing <i>CRB1</i> variants from 50 international cohorts, including 73 patients from Moorfields Eye Hospital.<h4>Methods</h4>Phenotypes were reclassified using standardized diagnostic criteria. This evidence concerns the gene CRB1 and retinal disorder.