For mixed infectious-non-infectious multimorbidity, male sex, injection drug use (IDU), low CD4 count, thrombocytopenia and opportunistic infections were risk factors, whereas higher BMI and being married were protective.<h4>Conclusion</h4>Among relatively young Chinese PWH, multimorbidity increases rapidly after ART initiation, driven by metabolic and other incurable conditions centered on dyslipidemia. Here, CD4 is linked to Opportunistic infection.