HCMV DNA, immunoglobulin M (IgM), and immunoglobulin G (IgG) were measured at 3 timepoints: (<i>i</i>) 6-24 months before TB diagnosis (pre-TB visit), (<i>ii</i>) at TB diagnosis (TB visit), and (<i>iii</i>) 6-24 months after TB diagnosis (post-TB visit).<h4>Results</h4>We enrolled 34 TB cases and 68 controls, the majority of whom were male (56% vs 60%). The gene discussed is CD40LG; the disease is tuberculosis.