<h4>Objective</h4>To investigate the role and mechanism of the SREBP1/SNAI1 signalling pathway in the effect of brexpiprazole on the EMT and metastasis of CRC.<h4>Methods</h4>The effects of different concentrations of brexpiprazole on cell migration, cell invasion and protein expression <i>in vitro</i> were examined by cell scratch assays, Transwell assays, Western blotting, ELISA, immunofluorescence, and transmission electron microscopy. The gene discussed is SREBF1; the disease is colorectal carcinoma.