On the other hand, <i>in vivo</i> experiments revealed that brexpiprazole significantly inhibited the formation of CRC lung metastases, suppressed the expression of SREBP1(m), SNAI1and MMP9, and upregulated the expression of E-Cad and ZO1.<h4>Conclusion</h4>Brexpiprazole inhibits the migration, invasion and metastasis of CRC cells by inhibiting the SREBP1/SNAI1 signalling pathway and downregulating the expression of EMT-related factors. This evidence concerns the gene SREBF1 and colorectal carcinoma.