A model of CRC metastasis in nude mice was established, and Western blotting, HE staining, and PET/CT were utilised to explore the effects of brexpiprazole on CRC lung metastasis.<h4>Results</h4>Brexpiprazole significantly inhibited the migration and invasion of CRC cells; downregulated the expression of SREBP1(m), SNAI1 and MMP9; upregulated the expression of E-Cad and ZO1; and decreased the levels of secreted ICAM-1 and VEGF in the supernatant of CRC cells. This evidence concerns the gene TJP1 and colorectal carcinoma.