<h4>Objective</h4>To investigate the association between serum human epidermal growth factor receptor 2 (HER2) levels and metabolic syndrome (MS) in women and to explore the relationship between HER2 and the use of commonly prescribed metabolic medications.<h4>Methods</h4>A total of 532 women who visited Nanjing Drum Tower Hospital between January 2021 and January 2023 were enrolled. Here, ERBB2 is linked to metabolic syndrome.