Our study did not find any significant correlation between c-MYC expression with histologic grade, LVI, PNI, tumour stage, nodal status, molecular subtypes, and HIF-1α expression.<h4>Conclusion</h4>An increase in HIF-1α expression correlated with aggressive behaviour of cancer and a higher likelihood of metastatic tumours. Here, HIF1A is linked to metastatic neoplasm.