<h4>Objectives</h4>CD79B is a key component of the B-cell receptor complex, but its relevance in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) remains unclear.<h4>Methods</h4>We screened immune-related genes in public MDS microarray datasets, prioritized CD79B, and validated its expression in an independent MDS cohort, an AML cohort, and peripheral blood samples from patients with MDS or AML transformed from MDS. Here, CD79B is linked to acute myeloid leukemia.