Flow cytometry confirms that FBXL18 and IL15RA are responsive to inflammatory stimuli and supports their role in immune-mediated pathways relevant to iridocyclitis, underscoring its potential as a therapeutic target.<h4>Conclusion</h4>This study indicates that the polygenic factors shared between iridocyclitis and immune-mediated diseases are broadly distributed across the genome. This evidence concerns the gene FBXL18 and iridocyclitis.