Docking suggested plausible ligandability of CX3CR1, FCGR1A, and TLR5, nominating candidates such as valproic acid and CGP-52608 for follow-up testing.<h4>Conclusion</h4>An ET-anchored, 10-gene signature captures a clinically relevant axis of sepsis-associated immunosuppression and enables short-term mortality risk stratification. The gene discussed is CX3CR1; the disease is Sepsis.