The most prominent themes included "immune checkpoint," "tumor immune microenvironment," "ferroptosis mechanisms," "drug resistance," and "non-coding RNAs." Notably, the STAT3-ferroptosis axis and immune pathways were identified as key translational targets.<h4>Conclusion</h4>Ferroptosis has become an important research frontier in gastric cancer and is increasingly recognized as a promising therapeutic strategy to modulate the tumor immune microenvironment and enhance immunotherapy efficacy. Here, STAT3 is linked to gastric cancer.