NPC2 and lung adenocarcinoma: Additionally, the impact of NPC2 on Ribociclib sensitivity was investigated through drug correlation analysis and molecular docking, while the predictive value of NPC2 regarding immunotherapy benefits was validated using the immune cell infiltration analysis.<h4>Results</h4>Through multi-omics clustering, we identified two subtypes of lung adenocarcinoma associated with prognosis, with the CS1 subtype exhibiting the most favorable prognostic outcomes.