Serological profiling (NS1, anti-DENV IgM, and anti-DENV IgG), estimation of serum acute-phase reactants, clinico-laboratory parameters, and viral load were performed to classify dengue patients under dengue with warning signs (DWS+, <i>n</i> = 35), dengue without warning signs (DWS-, <i>n</i> = 74), and severe dengue (<i>n</i> = 5) (based on varying grades of severity) in accordance with the 2009 WHO guidelines. The gene discussed is CD40LG; the disease is dengue disease.