<i>In vivo</i>, IL-1β and CXCL2 signals were increased in the dual-inflammation model, supporting cross-disease consistency of this axis.<h4>Conclusions</h4>Our integrative analyses identify a shared, myeloid-centered IL-1β/chemokine inflammatory program across periodontitis and IBD, which may contribute to the oral-gut inflammatory axis. Here, CXCL2 is linked to periodontitis.