This study evaluated plasma levels of interleukin-1β (IL-1β) and microRNA-146a (miR-146a) in patients with SLE and explored their potential as diagnostic and prognostic biomarkers.<h4>Methods</h4>Blood samples were collected from 100 patients with SLE and 100 healthy controls. The gene discussed is IL1B; the disease is systemic lupus erythematosus.