On the other hand, the reactive oxygen species (ROS) generated by the MnO<sub>2</sub>-mediated Fenton-like reaction, OXP, and mPTT also induce immunogenic cell death (ICD) to boost adaptive immunity, as well as activate the cGAS-STING pathway through tumor DNA damage to reinforce innate immunity. The gene discussed is CGAS; the disease is neoplasm.