However, its role in SCC remains elusive.<h4>Methods</h4>To address the role of 4E-BP1 function in SCC pathogenesis, we employed a two-stage chemical carcinogenesis model in 4E-BP1-deficient mice.<h4>Results</h4>4E-BP1-deficient mice exhibited a significantly increased papilloma burden compared to wild-type controls, accompanied by enhanced keratinocyte proliferation and augmented tumor vascularization. This evidence concerns the gene EIF4EBP1 and papilloma.