SHapley Additive exPlanations (SHAP) and Local Interpretable Model-agnostic Explanations (LIME) analysis has distinguished CRP, Vitamin D, Obesity, HGB, and BM as the most dominant features.<h4>Discussion</h4>Likewise, we have also compared our work with other novel works and validated the performance of our model for the prediction of gallstones. The gene discussed is CRP; the disease is gallstones.