TFE3 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: An aggressive subtype termed translocation renal cell carcinoma (tRCC) is notably more difficult to detect than the common type, clear-cell RCC, in part due to interindividual variability of gene fusions of the transcription factor TFE3, the driving factor in tRCC.