<h4>Objective</h4>This study aimed to identify novel sepsis biomarkers by evaluating serum interleukin-1 receptor type 2 (IL1R2) for its diagnostic and prognostic utility, in light of the limitations of current markers like PCT and CRP.<h4>Methods</h4>A single-center retrospective analysis was conducted involving 55 sepsis patients and 42 non-sepsis controls. The gene discussed is IL1R2; the disease is Sepsis.