Glycolytic flux was evaluated via Western blotting and immunofluorescence; corneal nerve integrity and epithelial healing were assessed by βIII-tubulin staining and sodium fluorescein assay.<h4>Results</h4>Hyperglycemia upregulated BRG1 and glycolytic enzymes in diabetic corneal nerves. Here, SMARCA4 is linked to Hyperglycemia.