Logistic regression analyses demonstrated that increases in CGRP (P = .002) and CRP (P = .011), as well as CGRP (P = .001) and ESR (P < .001), were each significantly associated with higher odds of active disease.<h4>Conclusion</h4>The findings suggest that higher serum CGRP levels may contribute to the pathophysiology of RA, potentially indicating disease progression, joint damage, and supporting prognosis in the management of RA. The gene discussed is CALCA; the disease is rheumatoid arthritis.