The retinoic acid receptor-related orphan receptor gamma (RORγ) has been implicated in various cancers, but its role and mechanism in NSCLC remain unclear.<h4>Methods</h4>RORγ expression and its correlation with patient prognosis in NSCLC were assessed by integrating public database bioinformatics analysis, immunohistochemistry, and Western blot. Here, RORC is linked to cancer.