It has been well recognized that M-MDSCs and PMN-MDSCs both express multiple immunosuppressive signals within the tumor microenvironment, including arginase-1 (ARG1), inducible nitric oxide synthase (iNOS), programmed death-ligand 1 (PD-L1), and interleukin 10 (IL-10). This evidence concerns the gene NOS2 and neoplasm.