CD69 and neoplasm: In further support of its specific action on the tumor microenvironment, the high-fat diet condition enhanced the CD8+ T cell activation markers, such as CD25 and CD69 (Figure 7D), while concurrently reducing exhaustion markers, including TIM-3 and LAG-3 (Figure 7E), in tumor-infiltrating CD8+ T cells at day 17 post-inoculation.