IL6 and neoplasm: However, recent evidence indicates that senescent tumor cells secrete SASPs, including IL-6, IL-8, along with vascular endothelial growth factor (VEGF), which can foster malignant progression in adjacent cancer cells via various mechanisms, such as recruiting MDSCs, regulatory T cells, and M2 macrophages as well as remodeling the tumor microenvironment to facilitate tumor growth and metastasis [18,19].