Ultimately, 14 genes (CASP2, CDKN2A, FOXD1, FSCN1, ING5, LIMK1, NOTCH3, OXTR, PHGDH, PML, SERPINE1, SNAI1, SPHK1, and UBTD1) were identified as risk factors (HR > 1) and all showed upregulated expression in COAD. Here, NOTCH3 is linked to colon adenocarcinoma.