For the NF-κB pathway, the levels of phosphorylated inhibitor of κBα (p-IκBα)/IκBα and phosphorylated p65 (p-p65)/p65 were both significantly increased (p < 0.05) by 109.19 (±25.19)% and 173.00 (±15.89)%, respectively, in the periodontitis-induced control group compared to the normal group. This evidence concerns the gene NFKB1 and periodontitis.