Considering the adjacent tissue (and HP-responsive tumor contexts), HP primarily engages a cGMP–PKG–VASP/actin axis [44,45] with BK-channel and lipid-transport crosstalk [51], while at the same time, the cellular biological properties of the tumor remain under the control of ER/HSP90 signaling [49], integrin-ECM remodeling, stemness, and nutrient transport. This evidence concerns the gene PRKG1 and neoplasm.