This pro-tumorigenic role is not confined to HCC; in ovarian cancer, elevated frequencies of IL-10-secreting B cells in ascites correlate with disease advancement, decreased IFN-γ+CD8+ T-cell response, and increased presence of FoxP3+ Tregs [61,62].These clinical observations were substantiated by preclinical models. The gene discussed is IL10; the disease is hepatocellular carcinoma.