Using Gene Set Enrichment Analysis (GSEA), Howard Y. Chang et al. [54] found that in atypical B cells (IgD+CD27+CD11c+atypical B cells, ABCs)from patients with systemic lupus erythematosus (SLE), Xist RNA expression levels were higher than in healthy donors. This evidence concerns the gene CD27 and systemic lupus erythematosus.