Furthermore, the presence of specific syndromic features serves as a critical diagnostic filter independent of age; for instance, the identification of renal cysts, sensorineural deafness, or optic atrophy should trigger immediate genetic evaluation for syndromes like HNF1B-MODY or Wolfram syndrome, regardless of whether the diabetes onset fits the classical neonatal timeframe [34]. This evidence concerns the gene HNF1B and cystic kidney disease.