The IL6-JAK-STAT3 axis provides mechanistic link between inflammatory signaling and tumor progression, as IL-6 can activates Janus kinase (JAK) enzymes to promote STAT3 phosphorylation and nuclear translocation, thereby regulating transcriptional programs involved in inflammation, survival, and immune modulation [45,46,54,55]. The gene discussed is STAT3; the disease is neoplasm.