Conversely, in C2-GBM, distinct oncogenic roles were played by ADGRB1 (Adhesion G Protein-Coupled Receptor B1), MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor), TOP2A (DNA Topoisomerase II Alpha), KIFC1 (Kinesin Family Member C1), and BCL7A (BAF Chromatin Remodeling Complex Subunit BCL7A) (Figure 4G). This evidence concerns the gene TOP2A and glioblastoma.