We further prioritized subtype-specific high-expression prognostic DEGs as potential targets for small-molecule discovery, including F13A1 (Coagulation Factor XIII A Chain), CHI3L (Chitinase 3 Like 1), CXCL3 (C-X-C Motif Chemokine Ligand 3), FCGR2B (Fc Gamma Receptor IIb) in C1-GBM (log2 FC > 2), and VGF (VGF Nerve Growth Factor Inducible) and HOXA2 (Homeobox A2) in C2-GBM (log2 FC < −1). The gene discussed is F13A1; the disease is glioblastoma.