In C1-GBM, key tumor driver genes included BIRC3 (Baculoviral IAP Repeat Containing 3), MET (MET Proto-Oncogene, Receptor Tyrosine Kinase), COL1A1 (Collagen Type I Alpha 1 Chain), CR1 (Complement C3b/C4b Receptor 1), and IL7R (Interleukin 7 Receptor). The gene discussed is NTRK1; the disease is glioblastoma.