Correspondingly, MHC pathway-associated genes, including HLA-C (Major Histocompatibility Complex, Class I, C), HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1), HLA-DPB1 (Major Histocompatibility Complex, Class II, DP Beta 1), HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ Alpha 1), HLA-DQA2 (Major Histocompatibility Complex, Class II, DQ Alpha 2), HLA-DRB5 (Major Histocompatibility Complex, Class II, DR Beta 5), and HLA-DRB6 (Major Histocompatibility Complex, Class II, DR Beta 6), were significantly upregulated in C1-GBM (Supplementary Figure S4B). The gene discussed is HLA-DRB5; the disease is glioblastoma.