Among the selected hub genes, immunoglobulin κ variable 3-11 (IGKV3-11), leukocyte-associated immunoglobulin-like receptor 1 (LAIR1), vesicle-associated membrane protein 8 (VAMP8), type I collagen α2 chain (COL1A2), and plasminogen activator urokinase receptor (PLAUR) were highly expressed in C1-GBM, whereas cytoskeleton-associated protein 2-like (CKAP2L), serine protease 51 (PRSS51), microtubule-associated serine/threonine kinase 1 (MAST1), and SRY-box transcription factor 6 (SOX6) showed elevated expression in C2-GBM (Figure 2F). The gene discussed is CKAP2L; the disease is glioblastoma.