CircGFRA is abundantly expressed in HER-2 positive breast cancer, prevents apoptosis, and promotes breast cancer cell metastasis by adsorbing miR-1228 and upregulating the expression of apoptosis-inducing factor mitochondria-associated 2 (AIFM2), which is related to poor prognosis for breast cancer. The gene discussed is ERBB2; the disease is breast carcinoma.