Several phytocompounds, which have been reported to inhibit STAT3, not yet studied in connection with SSc, might have certain benefits (curcumin [145], resveratrol [146], epigallocatechin-3-gallate [147], ginsenosides [148], quercetin [149], pterostilbene [150], piperine [151], embelin [152], andrographolide [153], baicalein [154], luteolin [155], delphinidin [156], piceatannol [157], parthenolide [158], magnolol [159], and indirubin [160]). This evidence concerns the gene STAT3 and systemic sclerosis.