Additional evidence demonstrates that IRF5, IRF6, and IRF8 are also play key roles in hepatocytes: IRF5 mediates Fas-induced apoptosis [154], IRF6 suppresses PPARγ to reduce lipid accumulation [25], and IRF8 aggravates steatosis through a BMAL1/PPARγ axis [155]. This evidence concerns the gene IRF8 and steatosis.