APP and Alzheimer disease: Compared with the sham group, there were higher levels of APP relative content in the hippo-Aβ group and hippo-CuAβ group (both p < 0.05, Figure 8C), while only the hippo-CuAβ group had statistical increases in BACE1 relative content (p < 0.05, Figure 8D) in brain homogenates, consistent with previous studies where the two protein had higher content in AD [37].