The suppression of FBL by p53 led to modifications in rRNA methylation pattern at a single nucleotide level, which has been shown to impair translational fidelity and reprogram protein synthesis in favor of IRES-dependent translation of oncogenic transcripts such as C-MYC may reflect altered upstream signaling or leukemia-specific transcriptional landscapes [14,35]. This evidence concerns the gene FBL and leukemia.