CRHR1 and Mental deterioration: While some CRHR1 CNVs were significantly associated with objective cognitive impairments, they did not show an association with self-reported cognitive decline (Exon 1/210, p = 0.77; Exon 1/229, p = 0.57; Exon 8, p = 0.74; Exon 11, p = 0.91; Exon 14, p = 0.9; Figure 2), suggesting that subjective cognitive impairment may not be directly influenced by CRHR1 gene variations.