Given the central role of HIF-1 in metabolic reprogramming under hypoxic and pseudohypoxic conditions [40,41], and the importance of PDK3 in inhibiting pyruvate entry into the TCA cycle [42,43,44], decreased expression of these proteins suggests that the tested compounds may impair cancer cell adaptation to low-oxygen environments and alter metabolic homeostasis. Here, HIF1A is linked to cancer.