Conclusion: In a dermo-epidermally relevant in vitro model, CleodermTM functions as an active dermofunctional base, not merely a vehicle simultaneously tempering inflammatory signaling, preserving extracellular matrix integrity, and modulating mechanistic nodes (LL-37 and IGFBP-3) linked to rosacea and acne. The gene discussed is IGFBP3; the disease is acne.