HSPB1 enhances the angiogenesis of bEnd.3 cells, subsequently contributing to tumor growth in vivo, and serves as a critical gene in the invasion of the cavernous sinus in PitNETs, facilitating the remodeling of the tumor microenvironment by enhancing the formation of blood vessels in brain microvascular endothelial cells. The gene discussed is HSPB1; the disease is neoplasm.