For example, Fusobacterium nucleatum, frequently enriched in CRC patients, promotes tumorigenesis by activating NF-κB–mediated inflammatory pathways, enhancing IL-17A and IL-6 signaling, and suppressing cytotoxic T-cell activity through Fap2-dependent immune evasion mechanisms [54,55]. The gene discussed is NFKB1; the disease is colorectal carcinoma.