BDNF and precocious puberty: This is supported by evidence showing that girls with central precocious puberty have higher serum BDNF levels, and experimental models demonstrate that hypothalamic BDNF upregulation (via FTO-mediated N6-methyladenosine (m6A) demethylation) stimulates GnRH expression through the PI3K/Akt pathway, leading to earlier puberty onset [31].