NFKB1 and diabetic kidney disease: In diabetic nephropathy, NF-κB activation and its stimulation of the NLRP3 inflammasome promote renal inflammation and enhance the deposition of fibronectin and collagen in the kidney [32], leading to thickening of the glomerular basement membrane, glomerulosclerosis, podocyte injury, and ultimately renal fibrosis [33].