SOD1 and type 2 diabetes mellitus: In addition, similarly, Rafighi et al. evaluated the outcome of vitamin C and E supplementation for 3 months on T2DM patients, aged 30–60 years with BMI > 25, and found that the consumption of vitamin C, E and C plus E significantly reduced the levels of FBG and HbA1c and increased the levels of SOD and GSH in T2DM patients compared to the placebo group [86].