It has been found that the long-term intake of cooked tomatoes (around 200 g per day) can improve antioxidant status in patients with T2DM by increasing levels of antioxidant enzymes like SOD, GSH, GPx, and GR and reducing lipid peroxidation (MDA levels) after 30 days [217]. This evidence concerns the gene SOD1 and type 2 diabetes mellitus.