In addition, the expression of N-cadherin was weak in BPH-1 cells cultured alone, while co-culture with WPMY-1 cells significantly enhanced the expression of N-cadherin in BPH-1 cells, and the addition of kzl054 treatment significantly reduced the expression of N-cadherin (Figure 6E,F). Here, CDH2 is linked to benign prostatic hyperplasia.